Title: Computer simulation and optimisation of breast tomosynthesis parallel imaging configuration and reconstruction

Authors: Weihua Zhou; Nuhad Malalla; Zhenxi Zhang; Ying Chen

Addresses: Department of Electrical and Computer Engineering, Southern Illinois University, MC 6603, 1230 Lincoln Drive, Carbondale, IL 62901, USA ' Department of Electrical and Computer Engineering, Southern Illinois University, MC 6603, 1230 Lincoln Drive, Carbondale, IL 62901, USA ' The School of Life Science and Technology, Xi'an Jiao Tong University, Xi'an 710049, China ' Department of Electrical and Computer Engineering, Southern Illinois University, MC 6603, 1230 Lincoln Drive, Carbondale, IL 62901, USA

Abstract: Digital breast tomosynthesis is a new three-dimensional breast imaging technology that has demonstrated its advantages over mammography by reducing the structural ambiguity caused by overlapping tissues. The motion blur caused by the X-ray arm rotation in the traditional prototype tomosynthesis systems influences its application. New design of parallel imaging configurations also appear recently to eliminate the arm rotation with the fixed multi-beam X-ray sources. In this paper, image quality with different reconstruction algorithms and parallel imaging configurations were investigated. Computer simulations based on spheres and wires suggested that the wide view angle range benefited the removal of out-of-plane blur and the large projection number contributed to the smoothness of reconstructed objects.

Keywords: digital breast tomosynthesis; image reconstruction; imaging configuration; simulation; optimisation; breast cancer detection; breast imaging; overlapping tissues; digital tomosynthesis; parallel imaging; image quality; motion blur.

DOI: 10.1504/IJCBDD.2015.071169

International Journal of Computational Biology and Drug Design, 2015 Vol.8 No.2, pp.139 - 149

Published online: 13 Aug 2015 *

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