Authors: Sigen Wang; Xin Qian
Addresses: FROS Radiation Oncology Cyberknife Center, Manhattan Radiation Oncology, New York, NY 10002, USA ' Department of Radiation Oncology, New York Presbyterian Hospital, Columbia University, New York, NY 10032, USA
Abstract: The radiation effects in tissue depend not only on dose but also on volume exposed, for example, the smaller the volume, the greater the tolerance. Microbeam radiation therapy (MRT), which exploits this effect, can only be achieved with synchrotron X-rays owing to their extraordinarily slight divergence. MRT research over the past 20 years has yielded many results from preclinical trials based on different animal models, including mice, rats, piglets and rabbits. Typically, targets are exposed to multiple quasi-parallel slices of radiation some tens of micrometres wide with on-centre separations of several hundred micrometres. The microplanar beams are produced by a multi-slit collimator, which cuts horizontally microscopic beam sectors from a wiggler-generated fan beam. Peak entrance doses of several hundreds of Gy are surprisingly well tolerated by normal tissues and at the same time show a preferential damage of malignant tumour tissues.
Keywords: microbeam radiation therapy; MRT; synchrotron-generated X-rays; normal tissue sparing effect; preferential tumoricidal effect; tissue tolerance; malignant tumours; tumour tissues; cancer research.
International Journal of Computational Biology and Drug Design, 2015 Vol.8 No.2, pp.127 - 138
Available online: 13 Aug 2015 *Full-text access for editors Access for subscribers Purchase this article Comment on this article