Title: Fabrication of poly (lactic acid)/hydroxyapatite (PLA/HAp) porous nanocomposite for bone regeneration

Authors: Dinh Thi Mai Thanh; Pham Thi Thu Trang; Ho Thu Huong; Pham Thi Nam; Nguyen Thu Phuong; Nguyen Thi Thu Trang; Thai Hoang; Tran Dai Lam; Jun Seo-Park

Addresses: Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay Distr., Hanoi, Vietnam ' Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay Distr., Hanoi, Vietnam ' Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay Distr., Hanoi, Vietnam ' Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay Distr., Hanoi, Vietnam ' Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay Distr., Hanoi, Vietnam ' Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay Distr., Hanoi, Vietnam ' Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay Distr., Hanoi, Vietnam ' Institute of Materials Science (IMS), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Street, Cau Giay Distr., Hanoi, Vietnam ' Department of Chemical Engineering, Hankyong National University, 327 Jungang-ro, Anseong-si, Gyeonggi-do, 456-749, South Korea

Abstract: In this study, a poly (lactic acid)/hydroxyapatite (PLA/HAp) porous nanocomposite was fabricated by melt mixing method. Polyethylene oxide (PEO) was added into the nanocomposite to improve compatibility of HAp in the PLA matrix. A porous structure of the nanocomposite was created by using a salt (NaCl) which leaches in water. The influence of HAp's weight, compatibiliser content of porous agent on morphology and mechanical properties of PLA/HAp nanocomposite was investigated by SEM and tensile testing method. The obtained results indicated that the nanocomposite containing 20 wt% HAp, 5 wt% PEO, and an amount of NaCl in proportion with PLA weight (1 : 1) had good mechanical properties with a promising Young's modulus close to the one of cancellous bone (530 MPa) as well as a high porosity. The invitro tests of nanocomposite in simulated body fluids (SBF) were carried out and then pH of SBF solution, variation of material mass (Δm), morphology and phase structure of the nanocomposite were also estimated. The results showed that pH decreased, and Δm had positive or negative values depending on composition and surface of material formed by HAp crystals and the hydrolysis of PLA during immersion time.

Keywords: poly lactic acid; PLA; hydroxyapatite; HAp; PLA/HAp nanocomposites; compatibiliser content; porous nanocomposites; bone regeneration; SBF; simulated body fluids; Young's modulus; tensile strength; nanotechnology; polyethylene oxide; PEO; biomedical engineering.

DOI: 10.1504/IJNT.2015.067897

International Journal of Nanotechnology, 2015 Vol.12 No.5/6/7, pp.391 - 404

Available online: 03 Mar 2015

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