Title: Bionanosilver-poly (methyl 2-methylpropenoate) electrospun nanofibre as a potent antibacterial against multidrug resistant bacteria

Authors: M.A. Abu-Saied; E.E. Hafez; T.H. Taha; Khalil Abdelrazek Khalil

Addresses: Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technology Applications (SRTA-CITY), New Borg El-Arab City, 21934, Alexandria, Egypt ' City for Scientific Research and Technology Applications, Arid Lands Cultivation Research Institute (ALCRI), Plant Protection and Bimolecular Diagnosis Department, New Borg El-Arab City, 21934, Alexandria, Egypt ' Biology Department, Faculty of Science, King Khalid University, Abha, 9004, Saudi Arabia; Environmental Biotechnology Department, GEBRI-Institute, City for Scientific Research and Technology Applications (SRTA-CITY), New Borg El-Arab City 21934, Alexandria, Egypt ' Department of Mechanical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia; Faculty of Energy Engineering, Aswan University, Aswan, Egypt

Abstract: Poly (methyl 2-methylpropenoate) PMMA [(C5O2H8)n] and bionanosilver are known to have inhibitory and bactericidal effects. In this study, Bacillus subtilis was used to produce bionanosilver particles that were characterised using SEM and FE-SEM. The bionanosilver were mixed with PMMA and dissolving in dimethylformamide (DMF) to produce bionanosilver-nanofibre (bionanofibre) using electrospun. The surface morphology was investigated by SEM. The activity of bionanofibre was examined as antibacterial against nine human pathogenic bacteria and the results were compared with different generic antibiotics. The bionanofibre showed high antibacterial activity and it was found that bionanofibre more specific for Methicillin-resistant Staphylococcus aureus (MRSA) especially in liquid culture with low concentrations.

Keywords: electrospinning; antibacterial activity; bionanosilver PMMA; electrospun nanofibre; multidrug resistant bacteria; drug resistance; nanotechnology; MRSA; nanoparticles; Bacillus subtilis; surface morphology; bionanofibre; antibiotics.

DOI: 10.1504/IJNP.2014.067606

International Journal of Nanoparticles, 2014 Vol.7 No.3/4, pp.190 - 202

Available online: 17 Feb 2015 *

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