Title: Genomic epidemiology of prostate cancer, family history approach, and the adoption of socio-ecological model to increase screening among American adult males

Authors: E. William Ebomoyi

Addresses: Department of Health Studies College of Health Sciences, Chicago State University, Chicago, Illinois 60628-1598, USA

Abstract: This project compared the deadly impact of prostate cancer in African-Americans and Caucasians and identified the gene-chromosomes which serve as precursors for this type of cancer. Innovative genomic techniques for screening and detecting prostate cancer were discussed. A comprehensive family history approach for screening at risk family members was illustrated. The succinct rationales for the socio-ecological model were presented and the relevance for screening using this model was critically analysed. To ensure that patients receive the precise chemotherapy, the concept of pharmacogenomics was presented as mechanism to ensure that the correct drug is administered in the right dose, at the right time to patients of different ethnic groups, based on their specific DNA sequence in order to avoid the onset of imperfect specificity and iatrogenic diseases. A comprehensive analysis of precision medicine which consists of predictive, preventive, personalised, and participatory innovative approach in genomic medicine was presented. Molecular science was predicted to enable oncologists to maximise treatment effectiveness while avoiding potentially life-threatening side-effects.

Keywords: genomic epidemiology; prostate cancer genome; family history; socio-ecological models; African-Americans; pharmacogenomics; precision medicine; DNA sequencing; screening; therapeutic intervention; gene chromosomes; chemotherapy; ethnic groups; cancer treatment.

DOI: 10.1504/IJMEI.2014.063182

International Journal of Medical Engineering and Informatics, 2014 Vol.6 No.3, pp.238 - 251

Available online: 04 Jul 2014 *

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