Article: Flow through coated and non-coated coronary stented arteries: an overview Journal: International Journal of Biomedical Engineering and Technology (IJBET) 2014 Vol.14 No.4 pp.344 - 367 Abstract: This paper reviews the recent literature (2005-2013) on stent applications and their advancement since recent controversies. The objective of this paper is to compare flow characteristics under various arterial conditions. It also includes a comparison of stent geometries to determine hemodynamically favourable stents. In spite of many advantages, Bare Metal Stents (BMS) are found to be unfavourable due to revascularisation and studies on stents, based on flow and design, recommend coatings of stent. In comparison with BMS, coated stents proved to be more effective resulting in a low hyperemic trans-stent gradient of about 1.2-8.1 mmHg. Most of the metal coatings have less fluoroscopic visibility and low tensile strengths which led to the study of drug-eluting stents. The drug-eluting stents control restenosis and target vessel revascularisation by 83-91%, but are limited by co-morbidities. Biodegradable stents, on the other hand, inhibit smooth muscle cell proliferation and a decrease in neointimal proliferation. At present, research on polymer, carbon and biodegradable stents are actively pursued in improving stent therapy through better design. Inderscience Publishers - linking academia, business and industry through research

Title: Flow through coated and non-coated coronary stented arteries: an overview

Authors: A. Gogineni; T.S. Ravigururajan

Addresses: Department of Mechanical Engineering, Wichita State University, Wichita, KS 67260, USA ' Department of Mechanical Engineering, Wichita State University, Wichita, KS 67260, USA

Abstract: This paper reviews the recent literature (2005-2013) on stent applications and their advancement since recent controversies. The objective of this paper is to compare flow characteristics under various arterial conditions. It also includes a comparison of stent geometries to determine hemodynamically favourable stents. In spite of many advantages, Bare Metal Stents (BMS) are found to be unfavourable due to revascularisation and studies on stents, based on flow and design, recommend coatings of stent. In comparison with BMS, coated stents proved to be more effective resulting in a low hyperemic trans-stent gradient of about 1.2-8.1 mmHg. Most of the metal coatings have less fluoroscopic visibility and low tensile strengths which led to the study of drug-eluting stents. The drug-eluting stents control restenosis and target vessel revascularisation by 83-91%, but are limited by co-morbidities. Biodegradable stents, on the other hand, inhibit smooth muscle cell proliferation and a decrease in neointimal proliferation. At present, research on polymer, carbon and biodegradable stents are actively pursued in improving stent therapy through better design.

Keywords: stent advancements; stent limitations; biodegradable stents; coated stents; blockage; blood flow; biomedical engineering; coronary arteries; stent geometries; hemodynamics; polymer stents; carbon stents; cardiovascular diseases; vascular stents; atherosclerosis.

DOI: 10.1504/IJBET.2014.060539

International Journal of Biomedical Engineering and Technology, 2014 Vol.14 No.4, pp.344 - 367

Received: 21 Oct 2013
Accepted: 05 Feb 2014
Published online: 21 Oct 2014 *

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Title: Flow through coated and non-coated coronary stented arteries: an overview

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