Title: Global genomic epidemiology of BRCA1/BRCA2; breast cancer associated genes and adoption of the health belief model to disseminate health education about compliance with precision (P4) medical science

Authors: E. William Ebomoyi; Josephine Ebomoyi

Addresses: Department of Health Studies, College of Health Sciences, Chicago State University, Chicago, Illinois 60628-1598, USA ' Molecular Biology Unit, North Western Memorial Hospital, 541 N. Fairbank Suite 2500, Chicago, Illinois 60611, USA

Abstract: This study reviewed the global, genomic epidemiology impact of gene mutations associated with BRCA1 and BRCA2 and the unnecessary mortality and morbidity associated with breast cancer. The project discussed the financial impact of breast cancer as a disease burden which necessitates innovative medical intervention and powerful genomic technology. For the first time, the authors advocate the crucial linkage of the Health Belief Model in accentuating life-saving attributes of precision medicine and the diagnostic molecular science in screening at risk women, and mothers of child bearing age for gene mutations involving BRCA1, BRAC2, TP53,PTEN, ST11/LKB1, CDH1, CHEK2 and ATM among other. Besides, the serendipitous benefits of globalisation have facilitated the process of disseminating innovative precision medicine to the developed, developing and least developed nations worldwide. The authors provided a list of potential humanitarian agencies from which indigent patients could solicit assistance to ensure that their positive diagnostic test for breast cancer gene(s) does not culminate in their imminent death sentence. Finally, recommendations were made about compliance with stringent exercise schedules and consumption of diet rich in polyphenols and other photochemical nutrients to sequester lethal gene chromosomes while enhancing those genes that code for graceful aging.

Keywords: global genome epidemiology; breast cancer; BRCA1; BRAC2; technological innovation; genome technology; globalisation; humanitarian agencies; movie stars; film stars; health belief model; health education; gene mutations; financial impact; cancer screening; precision medicine; diagnostic molecular science; exercise schedules; diet; polyphenols; photochemical nutrients.

DOI: 10.1504/IJMEI.2014.060249

International Journal of Medical Engineering and Informatics, 2014 Vol.6 No.2, pp.150 - 164

Available online: 01 Apr 2014 *

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