Title: Structural formation of inclusion complex nanoparticles from α-cyclodextrin and polysebacic acid

Authors: Pi-Che Chen; Di-Yao Hsu; Po-Da Hong; Adhimoorthy Prasannan; Truong-Le Bich-Tram

Addresses: Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan ' Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan ' Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan ' Materials Technology Program, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan ' Materials Technology Program, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan

Abstract: Inclusion complexes (IC) of α-cyclodextrin (α-CD) and biodegradable polysebacic acid (PSA) are prepared by using two different conditions of pH values. Interestingly, IC prepared at neutral pH (pH 7) shows turbidity and then into white precipitate, while IC prepared at alkaline pH (pH 10) forms into a clear solution, indicating the pH dependent behaviour of the IC and its formation of supramolecular assembly varies significantly by changing the pH. Moreover, it is found that by changing the pH, the affinity of the guest molecules with the CD cavity differs from strong intermolecular hydrogen bonding to weakly electrostatic interaction between PSA and α-CD. All experimental results suggest that the PSA chains are included into the α-CD cavity and the nanostructure of IC possesses a channel structure. PSA self-assembled into nanostructures in alkaline solution upon the addition of α-CD. The nanostructures produced were vesicular in shape as observed by TEM and hydrodynamic radius (Rh) obtained from DLS was ca.128 nm.

Keywords: alpha-cyclodextrin; polysebacic acid; biodegradable PSA; inclusion complex; nanostructures; self-assembly; nanoparticles; nanotechnology.

DOI: 10.1504/IJNT.2013.058142

International Journal of Nanotechnology, 2013 Vol.10 No.10/11, pp.1007 - 1024

Available online: 08 Dec 2013 *

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