Title: Development of fabrication technique in nano-scale resveratrol by collagen

Authors: Juin-Hong Cherng; Shu-Jen Chang; Jue-Zong Yeh; Yao-Wen Hung; Hsin-Chih Lai; Nien-Hsien Liou; Chung-Hsing Li; Chung-Ang Tsao; Cheng-Che Liu

Addresses: School of Dentistry, National Defense Medical Center, Taipei, Taiwan ' Department of Dentistry, National Yang-Ming University, Taipei, Taiwan ' Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan ' Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan ' Department of Medical Biotechnology and Laboratory, Chang Gung University, Taoyuan, Taiwan ' Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan ' School of Dentistry, National Defense Medical Center, Taipei, Taiwan ' Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan; Case Western Reserve University, Taipei, Taiwan ' Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Engineering Technology-Doctoral, National Taipei University of Technology, Taipei, Taiwan

Abstract: Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV), is found in various plants, including grapes, berries and peanuts. It is also present in wines, especially red wines. RSV has potent antioxidant, anti-inflammatory, and chemo-protective properties used as a biologically active supplement in the prophylaxis of myocardial infarction, diabetes, and tumours. The aim of this study was using nanotechnology to develop and examine a nanoparticle RSV. The techniques described the particles of nano RSV as having a size of 150-200 nm. In the evidence, we successfully developed a novel method of nano-RSV manufacture and demonstrated that this method could circumvent the physicochemical drawbacks of raw RSV with respect to dissolution, such as the reduction of particle size and gradually release from collagen materials. The scanning electron microscopy (SEM) data have shown the RSV nanoparticles in the collagen material, and Fourier transform infrared spectroscopy (FTIR) detected the adsorbed RSV nanoparticles at 950-1000 nm. In theory, collagen has similar properties to an emulsion/solvent that cause nanoformation of RSV under homogeneity of stirring. To study the biocompatibility, we also employed an in vitro model to estimate the potential of the collagen materials contained with RSV nanoparticles to observe the cell growth. This paper presents an anticipation of nanotechnology for the nanoparticle RSV production that may provide high efficacy pharmacology in future.

Keywords: RSV nanoparticles; fabrication; nanoscale resveratrol; nanotechnology; SEM; scanning electron microscopy; collagen; biocompability; myocardial infarction; diabetes; tumours; cell growth.

DOI: 10.1504/IJNT.2013.058124

International Journal of Nanotechnology, 2013 Vol.10 No.10/11, pp.984 - 995

Available online: 08 Dec 2013 *

Full-text access for editors Access for subscribers Purchase this article Comment on this article