Title: Biomedical optical analytical techniques to analyse the medicinal drugs and optical properties of tissues

Authors: G.S. Uthayakumar; A. Sivasubramanian

Addresses: Department of Electronics and Communication Engineering, St. Joseph's College of Engineering, Chennai 600119, Tamil Nadu, India ' Department of Electronics and Communication Engineering, St. Joseph's College of Engineering, Chennai 600119, Tamil Nadu, India

Abstract: In this research paper, the biomedical optical analytical techniques such as ultra-violet spectroscopy, Fourier transform infrared spectroscopy and Fourier transform-Raman spectroscopy are used to characterise and quantise the medicinal drugs. The hydroxyl group and methyl group was assigned to the wave numbers 3230.67 cm⁻¹ and 2928.50 cm⁻¹. The functional groups are also identified -N=C=O, -N=C=S, -N=C=N-, -N₃ at 4.67 μm. The CH, CH₂, and CH₃ three bands with strong intensity are assigned to the wave numbers 2985 cm⁻¹ to 2850 cm⁻¹. The FT-Raman spectra is obtained for the blue sample, the functional group C≡C is assigned to the wave number 2129.84 to 2191.41 cm⁻¹. The wave numbers 2558.71-2620.73 cm⁻¹ are obtained for the functional bond -S-H. The wave number 1610.95 cm⁻¹ is obtained for the C=N functional group. In this paper one sample namely Fibril-SF is taken by a patient and his saliva sample is collected for Fourier Transform Infrared spectroscopy test to analyse the reaction of drugs with human body tissues.

Keywords: absorption; scattering; transillumination; Fourier transform infrared spectroscopy; Fourier transform-Raman spectroscopy; biomedical optical analysis; medicinal drugs; optical properties; human body tissues; drug reactions.

DOI: 10.1504/IJBET.2013.056284

International Journal of Biomedical Engineering and Technology, 2013 Vol.12 No.1, pp.38 - 59

Received: 01 Oct 2012
Accepted: 25 Jun 2013
Published online: 27 Sep 2014 *

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