Title: Using an ultrasound circular transducer to treat Ehrlich ascites carcinoma implanted in mice in vivo and in vitro

Authors: Ashraf T. Ibrahim; Moustafa M. Mohamed

Addresses: EED - Faculty of Engineering, Alexandria University, Alexandria, Egypt ' Biophysics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt

Abstract: This paper describes a modelling method of the tissue temperature evolution over two times in hyperthermia. This approach is used to simulate the Ehrlich ascites carcinoma implanted in mice curative treatment by a percutaneous ultrasound. Bioheat transfer equation was algebraically solved after a Fourier transformation over the space coordinates. The implementation and boundary conditions of this method were shown and compared to the finite difference method. Circular ultrasound transducer was used to rise the temperature in the skin of mice and estimate the tumour temperature rise using the finite different conditions of ultrasonic frequency, intensity and waveform (continuous and pulsed) were studied in vitro and in vivo. Density and ultrasonic attenuation of excised tumour tissues were measured in vitro with and without drugs and used to estimate the temperature rises due to ultrasonic absorption. The ultrasound pressure and temperature rise profiles' results obtained from our study were used to discuss the possible mechanisms of ultrasonic action in tumour cells. Finally, we studied the temperature distribution in a multi-layer medium. The results obtained were compared to those obtained using other methods.

Keywords: ultrasound; thermal therapy; ultrasonic transducers; cancer treatment; Ehrlich tumour; modelling; Ehrlich ascites carcinoma; mice; tissue temperature; hyperthermia; simulation; bioheat transfer; heat transfer; tumour temperature; skin temperature; temperature distribution.

DOI: 10.1504/IJBET.2013.055675

International Journal of Biomedical Engineering and Technology, 2013 Vol.11 No.4, pp.411 - 430

Received: 09 Aug 2012
Accepted: 04 Apr 2013
Published online: 27 Sep 2014 *

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