Title: BoneNET: a network model of bone microstructure and dynamics

Authors: Taehyong Kim; Lawrence Bone; Murali Ramanathan; Aidong Zhang

Addresses: Department of Computer Science and Engineering, State University of New York at Buffalo, 201 Bell Hall, Buffalo 14260-2000, New York, USA ' Department of Orthopedics, State University of New York at Buffalo, 462 Grider Street, Buffalo 14215, New York, USA ' Department of Pharmaceutical Sciences, State University of New York at Buffalo, 517 Hochstetter Hall, Buffalo 14260-1200, New York, USA ' Department of Computer Science and Engineering, State University of New York at Buffalo, 201 Bell Hall, Buffalo 14260-2000, New York, USA

Abstract: We develop a network model of bone microstructure and dynamics, BoneNET, which is capable of quantitative assessment of Bone Mineral Density (BMD) and bone remodelling dynamics. First, we introduce a network model of bone microstructure by describing structural properties and process of bone network modelling. Secondly, we explain a mathematical model of bone microstructure by analysing the density for mineralised fibres of bone microstructure. Finally, we provide a bone remodelling dynamics among osteoblast and osteoclast and study bone networks by proposing several measurements to calculate bone strength and identify critical elements in bone microstructure.

Keywords: computational modelling; bone microstructure; bone strength; BMD; bone mineral density; bone remodelling dynamics; osteoporosis; mathematical modelling; osteoblast; osteoclast.

DOI: 10.1504/IJDMB.2013.055494

International Journal of Data Mining and Bioinformatics, 2013 Vol.8 No.2, pp.123 - 149

Received: 28 Apr 2011
Accepted: 28 Apr 2011
Published online: 20 Oct 2014 *

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