Title: Breast tomosynthesis imaging configuration analysis

Authors: Cleveland E. Rayford II; Weihua Zhou; Ying Chen

Addresses: Department of Electrical and Computer Engineering, Southern Illinois University, Carbondale, IL 62901, USA ' Department of Electrical and Computer Engineering, Southern Illinois University, Carbondale, IL 62901, USA ' Department of Electrical and Computer Engineering, Southern Illinois University, Carbondale, IL 62901, USA

Abstract: Traditional two-dimensional (2D) X-ray mammography is the most commonly used method for breast cancer diagnosis. Recently, a three-dimensional (3D) Digital Breast Tomosynthesis (DBT) system has been invented, which is likely to challenge the current mammography technology. The DBT system provides stunning 3D information, giving physicians increased detail of anatomical information, while reducing the chance of false negative screening. In this research, two reconstruction algorithms, Back Projection (BP) and Shift-And-Add (SAA), were used to investigate and compare View Angle (VA) and the number of projection images (N) with parallel imaging configurations. In addition, in order to better determine which method displayed better-quality imaging, Modulation Transfer Function (MTF) analyses were conducted with both algorithms, ultimately producing results which improve upon better breast cancer detection. Research studies find evidence that early detection of the disease is the best way to conquer breast cancer, and earlier detection results in the increase of life span for the affected person.

Keywords: mammography; digital breast tomosynthesis; impulse response; SAA; shift-and-add; back projection; image reconstruction; imaging configuration analysis; breast cancer diagnosis; modulation transfer function; MTF.

DOI: 10.1504/IJCBDD.2013.055460

International Journal of Computational Biology and Drug Design, 2013 Vol.6 No.3, pp.255 - 262

Published online: 29 Jul 2013 *

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