Title: Fate of SiC and TiC nanoparticle dispersions in human reconstituted gastric fluid

Authors: Jorge Mejia; Olivier Toussaint; Bernard Masereel; Stéphane Lucas

Addresses: Research Centre for the Physics of Matter and Radiation (LARN-PMR – NARILIS), University of Namur, Rue de Bruxelles 61, B-5000 Namur, Belgium ' Research Unit in Cellular Biology (URBC – NARILIS), University of Namur, Rue de Bruxelles 61, B-5000 Namur, Belgium ' Department of Pharmacy NAMEDIC, Namur Thrombosis and Hemostasis Center (NTHC), NARILIS, University of Namur, Rue de Bruxelles 61, B-5000 Namur, Belgium ' Research Centre for the Physics of Matter and Radiation (LARN-PMR – NARILIS), University of Namur, Rue de Bruxelles 61, B-5000 Namur, Belgium

Abstract: In this work, we explore the evolution of the physicochemical properties of silicon carbide and titanium carbide nanoparticles in human reconstituted gastric fluid in the conditions of a normal digestion. The nanoparticles were pre-dispersed in water or in a pluronic F108 solution. Key parameters as the particle size distribution and the surface composition of the nanoparticles were monitored. The results show that the modifications produced during the simulated digestion are dispersion medium dependent. Carbon and nitrogen were found to be adsorbed on the surface of both nanoparticles in a dispersion medium dependent way. The reported results contribute to understand the biological impact of these nanoparticles in biofluids and biocompatible media.

Keywords: SiC nanoparticles; TiC nanoparticles; silicon carbide; titanium carbide; human reconstituted gastric fluids; HRGF; particle size distribution; PSD; surface composition; nanotechnology; nanoparticle dispersion; normal digestion; simulation; carbon adsorption; nitrogen adsorption; biofluids; biocompatible media.

DOI: 10.1504/IJNBM.2012.051706

International Journal of Nano and Biomaterials, 2012 Vol.4 No.3/4, pp.243 - 255

Available online: 27 Jan 2013 *

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