You can view the full text of this article for free using the link below.

Title: A promising tool for biomolecular nanotechnology - bionanoparticles

Authors: K. Pavan Kumar; V. Chinnapa Reddy; S. Vinod Hulle Kumar; P.R. Radhika; T. Sivakumar

Addresses: Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, India ' Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, India ' Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, India ' Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, India ' Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, India

Abstract: Bionanoparticles are naturally produced entities that are of nanometre dimension. Viruses like cowpea mosaic virus (CPMV), cowpea chlorotic mottle virus (CCMV), turnip yellow mosaic virus (TYMV), tobacco mosaic virus (TMV), adenovirus, ferritin, and enzyme complexes exemplify these systems, with their precise arrangements of tens to hundreds of molecules into highly organised scaffolds for nucleic acid packaging, metal storage, catalysis or sequestering reactions at the nanometre scale. The purification method involves an efficient tangential flow filtration (TFF), diafiltration and various chromatographic techniques. The bionanoparticles are characterised by using the transmission electron microscopy, scanning electron microscopy and various spectrophotometric methods. One promising medical application of nanotechnology is the targeted delivery of pharmaceuticals to specific cells within an organism under minimisation of adverse effects for the remaining cells by nanoscale carriers. The branch of bionanotechnology in which naturally occurring nanoparticles are modified and manipulated for various applications is a rich and newly emerging field of research.

Keywords: bionanoparticles; viruses; proteins; drug delivery; biomolecular nanotechnology; nanoparticles; purification; targeted delivery; specific cells.

DOI: 10.1504/IJBNN.2012.051219

International Journal of Biomedical Nanoscience and Nanotechnology, 2012 Vol.2 No.3/4, pp.207 - 231

Available online: 28 Dec 2012 *

Full-text access for editors Access for subscribers Free access Comment on this article