Article: A chronic very low dose of gamma-rays alters cell adhesion Journal: International Journal of Low Radiation (IJLR) 2011 Vol.8 No.5/6 pp.412 - 428 Abstract: The biological effects of very low doses of ionising radiation are difficult to assess. We previously observed a delay of death by lymphoma in two different mouse strains continuously irradiated (γ-rays) with a dose rate of 10 cGy year−1. Cellular mechanisms likely to lead to slowing tumour growth were explored. Human lymphoid and epithelial cell lines (HL60 and MCF7) were irradiated in vitro at very low dose rate of 4 cGy month−1. Proliferation was not modified in HL60 and MCF7 cells. However, irradiated MCF7 adherent cells showed a lower cell attachment to support partly related to a slight decrease in expression levels of α6 and β4 integrins. We also observed a transient adaptive response during at least two weeks after the beginning of the irradiation in both cell lines. These results demonstrate the ability of tiny amounts of gamma-irradiation to alter cell attachment to support and to induce an adaptive response. Inderscience Publishers - linking academia, business and industry through research

Title: A chronic very low dose of gamma-rays alters cell adhesion

Authors: Laetitia Lacoste-Collin; Suzanne Jozan; Veronica Pereda; Monique Courtade-Saïdi

Addresses: Laboratoire d'Histologie-Embryologie, Faculté de Médecine de Rangueil, 133, route de Narbonne, F-31062 Toulouse Cedex 9, France. ' Laboratoire d'Histologie-Embryologie, Faculté de Médecine de Rangueil, 133, route de Narbonne, F-31062 Toulouse Cedex 9, France. ' GSBMS, Equipe AMIS, UMR UPS-CNRS, Faculté de Médecine, 37 Allées Jules Guesde, F-31073 Toulouse Cedex 3, France. ' Laboratoire d'Histologie-Embryologie, Faculté de Médecine de Rangueil, 133, route de Narbonne, F-31062 Toulouse Cedex 9, France; GSBMS, Equipe AMIS, UMR UPS-CNRS, Faculté de Médecine, 37 Allées Jules Guesde, F-31073 Toulouse Cedex 3, France

Abstract: The biological effects of very low doses of ionising radiation are difficult to assess. We previously observed a delay of death by lymphoma in two different mouse strains continuously irradiated (γ-rays) with a dose rate of 10 cGy year⁻¹. Cellular mechanisms likely to lead to slowing tumour growth were explored. Human lymphoid and epithelial cell lines (HL60 and MCF7) were irradiated in vitro at very low dose rate of 4 cGy month⁻¹. Proliferation was not modified in HL60 and MCF7 cells. However, irradiated MCF7 adherent cells showed a lower cell attachment to support partly related to a slight decrease in expression levels of α6 and β4 integrins. We also observed a transient adaptive response during at least two weeks after the beginning of the irradiation in both cell lines. These results demonstrate the ability of tiny amounts of gamma-irradiation to alter cell attachment to support and to induce an adaptive response.

Keywords: low-dose rate radiation; cell adhesion; adaptive response; HL60; MCF7; low radiation; gamma irradiation; ionising radiation; tumour growth.

DOI: 10.1504/IJLR.2011.047185

International Journal of Low Radiation, 2011 Vol.8 No.5/6, pp.412 - 428

Received: 28 Mar 2012
Accepted: 01 Apr 2012
Published online: 07 Feb 2015 *

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Title: A chronic very low dose of gamma-rays alters cell adhesion

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