A chronic very low dose of gamma-rays alters cell adhesion Online publication date: Sat, 07-Feb-2015
by Laetitia Lacoste-Collin; Suzanne Jozan; Veronica Pereda; Monique Courtade-Saïdi
International Journal of Low Radiation (IJLR), Vol. 8, No. 5/6, 2011
Abstract: The biological effects of very low doses of ionising radiation are difficult to assess. We previously observed a delay of death by lymphoma in two different mouse strains continuously irradiated (γ-rays) with a dose rate of 10 cGy year−1. Cellular mechanisms likely to lead to slowing tumour growth were explored. Human lymphoid and epithelial cell lines (HL60 and MCF7) were irradiated in vitro at very low dose rate of 4 cGy month−1. Proliferation was not modified in HL60 and MCF7 cells. However, irradiated MCF7 adherent cells showed a lower cell attachment to support partly related to a slight decrease in expression levels of α6 and β4 integrins. We also observed a transient adaptive response during at least two weeks after the beginning of the irradiation in both cell lines. These results demonstrate the ability of tiny amounts of gamma-irradiation to alter cell attachment to support and to induce an adaptive response.
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