Title: Investigation on in vivo and in vitro blood compatibility of polypyrrole-coated titanium for cardiovascular application

Authors: Jianping Fan; Aini Xie; Chengkun Xia; Chenggui Liu; Kailun Zhang

Addresses: Department of Cardiovascular Surgery, Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ' Department of Cardiovascular Surgery, Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ' Department of Cardiovascular Surgery, Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ' Department of Cardiovascular Surgery, Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ' Department of Cardiovascular Surgery, Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Abstract: To identify the suitability of a conducting polymer-polypyrrole for development of a surface modification strategy of titanium, we electrocoated the monomer of pyrrole on titanium surface and produced an adherent polypyrrole coating. Then, this coating was characterised in terms of its mechanical and physical properties and also evaluated for in vivo and in vitro blood compatibility. It was found polypyrrole is more compatible than the bare titanium material with blood and possesses superior adhesion strength to titanium substrate and may serve as an ideal platform for anticoagulant functionalisation of titanium surface in the future.

Keywords: cardiovascular applications; titanium; polypyrrole coatings; blood compatibility; biomaterials; surface modification; adhesion strength; anticoagulants.

DOI: 10.1504/IJBET.2012.046959

International Journal of Biomedical Engineering and Technology, 2012 Vol.8 No.4, pp.326 - 342

Published online: 12 Dec 2014 *

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