Title: Development of a 4D dosimetry simulation system in radiotherapy

Authors: Q. Jackie Wu; Danthai Thongphiew; Zhiheng Wang; Christopher Willett; Lawrence Marks; Fang-Fang Yin

Addresses: Department of Radiation Oncology, Duke University Medical Center, P.O. 3295, Durham, NC 27710, USA. ' Department of Radiation Oncology, Duke University Medical Center, P.O. 3295, Durham, NC 27710, USA. ' Department of Radiation Oncology, Duke University Medical Center, P.O. 3295, Durham, NC 27710, USA. ' Department of Radiation Oncology, Duke University Medical Center, P.O. 3295, Durham, NC 27710, USA. ' Department of Radiation Oncology, Duke University Medical Center, P.O. 3295, Durham, NC 27710, USA. ' Department of Radiation Oncology, Duke University Medical Center, P.O. 3295, Durham, NC 27710, USA

Abstract: 4D CT image sets are used to encode patient-organ motion and to calculate the dose delivered during each respiratory phase. The dose-per-phase is summarised to the total dose via deformable registration. The system incorporates the actual beam parameters and synchronises the beam motion (e.g., gantry/MLC motion of the DARC and MLC motion of the IMRT) to the patient's respiratory motion. Furthermore, this system incorporates different treatment techniques such as 3D conformal (3DCRT), dynamic arc (DARC), and Intensity-Modulated Radiation Therapy (IMRT), thus allows better understanding of organ motion effect on dose delivery, treatment techniques and corresponding optimal margins.

Keywords: 4D radiation therapy; respiratory motion; deformable registration; radiation dosimetry; radiotherapy treatment; 4DCT; CT images; medical imaging; computed tomography; liver cancer; organ motion; dose delivery; tumour motion.

DOI: 10.1504/IJBET.2012.046088

International Journal of Biomedical Engineering and Technology, 2012 Vol.8 No.2/3, pp.230 - 244

Available online: 18 Mar 2012 *

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