Title: A 4DRT simulation study using a synthetic 3.5D CT image with motion-free target of lung cancer based on 4DCT

Authors: Guang Li; Huchen Xie; Holly Ning; Naveen Arora; Aaron Brown; Peter Guion; Jason Cheng; Barabra Arora; Aradhana Kaushal; Deborah Citrin; Kevin Camphausen; Robert W. Miller

Addresses: Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA. ' Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg.10, CRC, Rm. B2-3561, 10 Center Dr, Bethesda, Maryland 20892, USA

Abstract: Four-Dimensional Radiotherapy (4DRT) planning based on 4D Computed Tomography (4DCT) is limited by drastically increased planning workload and unavoidably needed new software. We introduced a new concept of 3.5DCT for a simplified 4DRT planning. This 3.5DCT is synthesised from 4DCT by aligning the tumour centres in each phase, simulating a motion-compensated tumour from the beam eye's view. Four patients' 4DCTs were used for the 4DRT planning, which were compared with motion-trajectory-based and respiratory-gated plans. This simplified 4DRT plan shows dosimetric advantage of significant reduction of V95 and V20. This suggests that the static 3.5DCT image is sufficient for 4DRT planning.

Keywords: 4DRT; 4D radiation therapy; respiratory motion tracking; 4DCT; 4D computed tomography; 4DRT treatment planning; radiotherapy treatment; medical imaging; simulation; lung cancer; tumours.

DOI: 10.1504/IJBET.2012.046084

International Journal of Biomedical Engineering and Technology, 2012 Vol.8 No.2/3, pp.167 - 181

Available online: 18 Mar 2012 *

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