Title: Studies on controlled release of gold/tuberculosis drug complex entrapped polyethylene terephthalate-co-polylactic acid polymer nanoparticles

Authors: Kannaiyan Sathishkumar; Vaithilingam Selvaraj; Muthukaruppan Alagar

Addresses: Department of chemical Engineering, SSN College of Engineering, Kalavakkam-603110, India. ' Department of Chemistry, University College of Engineering-Villupuram, Anna University Chennai, Chennai-600 025, India. ' Department of Chemical Engineering, Anna University Chennai, Chennai-600 025, India

Abstract: Polyethylene terephthalate-polylactic acid copolymer (PET-co-PLA) was prepared by using bis (2-hydroxyethyl terephthalate) and lactic acid oligomer with manganese antimony glycoxide as a catalyst. Isoniazid (INH) containing polyethylene terephthalate-polylactic acid copolymer (PET-co-PLA) nanocapsules were prepared in the presence and absence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The morphologies of prepared nanocapsules were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The structure of copolymer was determined using nuclear magnetic resonance spectroscopy. The morphology of the prepared nanocapsules (PIA, containing PET-co-PLA, isoniazid and gold nanoparticles) differs substantially because of the presence of gold nanoparticles. From SEM and TEM measurements, the average size of the polymer nanocapsules and gold nanoparticles were found to be in range of 230-260 nm and 18-20 nm respectively. Polymer nanocapsules with gold show a prolonged controlled release with higher encapsulation efficiency compared to that of polymer nanocapsules in the absence of gold nanoparticles. It may be due to the more entrapping efficiency of gold and less diffusivity of drugs from the nanocapsules.

Keywords: gold nanoparticles; tuberculosis; polyethylene terephthalate-co-polylactic acid; polymer nanoparticles; biodegradable; isoniazid; PET-co-PLA nanocapsules; controlled release; drug release; nanotechnology.

DOI: 10.1504/IJNP.2011.043494

International Journal of Nanoparticles, 2011 Vol.4 No.4, pp.314 - 325

Received: 19 Nov 2009
Accepted: 14 Jul 2010
Published online: 13 Mar 2015 *

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