Title: A study of Cardiopulmonary interaction haemodynamics with detailed lumped parameter model

Authors: K. Hemalatha, M. Manivannan

Addresses: Biomedical Engineering Laboratory, Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India. ' Biomedical Engineering Laboratory, Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India

Abstract: A Cardiopulmonary (CP) model to study the interaction between Cardiovascular(CV) and Respiratory System (RPS) is presented. It includes detailed anatomical representations of CV, RPS and baroreflex control. The respiratory induced variations on CVS is realised by intrapleural pressure (Ppl). The state equations are solved using 4th order Runge-Kutta method. Sensitivity analysis is performed. The RPS influences on aortic pressure is presented for quite breathing and Valsalva Manuever and found have good agreement with literature data. Our model can simulate various CP diseases and therefore it can be used to study interactions hemodynamics in normal and pathological conditions.

Keywords: haemodynamics; lung mechanics; gas exchange; baroreflex control; intrapleural pressure; septum; lumped parameter modelling; cardiopulmonary models; cardiovascular system; respiratory system; aortic pressure; heart disease; lung disease; respiratory diseases.

DOI: 10.1504/IJBET.2011.041464

International Journal of Biomedical Engineering and Technology, 2011 Vol.6 No.3, pp.251 - 271

Published online: 21 Jan 2015 *

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