Title: Biomedical applications of organically modified bioconjugated silica nanoparticles

Authors: Kanniah Paulkumar, Ramaiah Arunachalam, Gurusamy Annadurai

Addresses: Environmental Nanotechnology Division, Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi – 627412, Tamil Nadu, India. ' Environmental Nanotechnology Division, Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi – 627412, Tamil Nadu, India. ' Environmental Nanotechnology Division, Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi &ndash 627412, Tamil Nadu, India

Abstract: Nanoparticles are one of the most important prominent areas in the field of nanotechnology, with a broad significant role in current life sciences and human healthcare applications. Among the nanoparticles silica nanoparticles are explored in many biological applications because their size dependent novel properties and functions differ drastically from those of the bulk materials. In biomedical research, silica nanoparticles act as a novel class of nanodetector or nanoseparator with unique advantages due to their size, biocompatibility, specificity and other size dependent properties. In this review, we describe the applications of silica nanoparticles in the field of biomedical nanotechnology such as highly sensitive bioanalysis systems for targeted drug delivery, clinical diagnosis and immunoassay.

Keywords: silica nanoparticles; bioanalysis; bioseparation; cellular imaging; nanomedicine; gene delivery; biomedical engineering; bioengineering; biomedical nanotechnology; nanodetectors; nanoseparators; biocompatibility; targeted drug delivery; clinical diagnosis; immunoassay.

DOI: 10.1504/IJNT.2011.041436

International Journal of Nanotechnology, 2011 Vol.8 No.8/9, pp.653 - 663

Published online: 22 Jul 2011 *

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