Title: Text mining and visualisation of Protein-Protein Interactions

Authors: Flora S. Tsai

Addresses: School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Block S2, 639798, Singapore

Abstract: The study of Protein-Protein Interactions (PPIs) is of great importance in determining the biological function and impact of proteins. However, the constant discovery of new PPIs makes it extremely time-consuming to manually extract information from new publications. In addition, it is necessary to view and simulate protein interactions in three dimensions. This paper presents a text mining and visualisation framework for finding details of PPIs that occur within a particular subcellular location. By obtaining the sequence of the amino acids at the interface of a protein interaction, one can obtain a deeper understanding about the function of the protein.

Keywords: text mining; visualisation; PPIs; protein-protein interactions; subcellular location; protein interactions; Pubmed abstracts; amino acid sequences; amino acids; protein functions.

DOI: 10.1504/IJCBDD.2011.041412

International Journal of Computational Biology and Drug Design, 2011 Vol.4 No.3, pp.239 - 244

Available online: 21 Jul 2011 *

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