Title: Thermometry on the nanometre-scale for biomedical applications using NMR spectroscopy

Authors: Anja U.B. Wolter, Rudiger Klingeler, Bernd Buchner

Addresses: Leibniz Institute for Solid State and Materials Research (IFW) Dresden, Helmholtzstr. 20, D-01069 Dresden, Germany. ' Leibniz Institute for Solid State and Materials Research (IFW) Dresden, Helmholtzstr. 20, D-01069 Dresden, Germany. ' Leibniz Institute for Solid State and Materials Research (IFW) Dresden, Helmholtzstr. 20, D-01069 Dresden, Germany

Abstract: Accurate temperature control with high spatial resolution is a challenging research topic in nano- and biotechnology. Due to their extraordinary physical and chemical properties carbon nanotubes reveal a promising potential as biomedical agents for temperature sensoring on the cellular level. Filling carbon nanotubes with tailored materials realises nanoscaled containers in which the active content is encapsulated by a protecting carbon shell. In particular, the filling with NMR active substances allows the usage as markers and temperature sensors. Their potential for biomedical applications is highlighted by temperature dependent NMR studies giving a proof-of-concept for a non-invasive temperature control on the cellular level.

Keywords: carbon nanotubes; CNT; temperature control; NMR; nuclear magnetic resonance; magnetic resonance imaging; MRI; nanotechnology; biomedical nanoscience; cells; nanotechnology.

DOI: 10.1504/IJBNN.2011.040996

International Journal of Biomedical Nanoscience and Nanotechnology, 2011 Vol.2 No.2, pp.99 - 111

Published online: 28 Jun 2011 *

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