Title: In vitro and in vivo intracellular delivery of quantum dots by maurocalcine

Authors: Narendra Ram, Isabelle Texier-Nogues, Karine Pernet-Gallay, Cathy Poillot, Fabienne Pirollet, Michel Ronjat, Annie Andrieux, Christophe Arnoult, T. Jean Daou, Michel De Waard

Addresses: Research group 3 'Calcium Channels, Functions and Pathologies', Grenoble Institute of Neuroscience, Universite Joseph Fourier, Site Sante, BP 170, 38042 Grenoble Cedex 09, France. ' CEA Grenoble/LETI-DTBS, 17 rue des Martyrs, 38054 Grenoble Cedex, France. ' Inserm U836, Grenoble Institute of Neuroscience, Universite Joseph Fourier, Site Sante Tronche, BP170, 38042 Grenoble, France. ' Research group 3 'Calcium Channels, Functions and Pathologies', Grenoble Institute of Neuroscience, Universite Joseph Fourier, Site Sante, BP 170, 38042 Grenoble Cedex 09, France. ' Research group 3 'Calcium Channels, Functions and Pathologies', Grenoble Institute of Neuroscience, Universite Joseph Fourier, Site Sante, BP 170, 38042 Grenoble Cedex 09, France. ' Research group 3 'Calcium Channels, Functions and Pathologies', Grenoble Institute of Neuroscience, Universite Joseph Fourier, Site Sante, BP 170, 38042 Grenoble Cedex 09, France. ' Research group 1 'Physiopathologie du Cytosquelette', Inserm U836, Grenoble Institute of Neuroscience, Universite Joseph Fourier, Site Sante Tronche, BP170, 38042 Grenoble, France. ' Research group 3 'Calcium Channels, Functions and Pathologies', Grenoble Institute of Neuroscience, Universite Joseph Fourier, Site Sante, BP 170, 38042 Grenoble Cedex 09, France. ' Equipe Materiaux a Porosite Controlee, Institut de Science des Materiaux de Mulhouse (IS2M) LRC CNRS, 7228 – UHA ENSCMu, Mulhouse, France. ' Research group 3 'Calcium Channels, Functions and Pathologies', Grenoble Institute of Neuroscience, Universite Joseph Fourier, Site Sante, BP 170, 38042 Grenoble Cedex 09, France

Abstract: Maurocalcine is a new member of the increasing family of cell penetrating peptides. We report for the first time that this peptide is able to deliver quantum dots inside a variety of cells, both in vitro and in vivo. In vivo, maurocalcine produces intracellular delivery of the nanoparticles without affecting the relative distribution of quantum dots within organs. The data stress out that maurocalcine can be used for intracellular delivery of functionalised nanoparticles in vivo.

Keywords: quantum dots; functionalised nanoparticles; maurocalcine; cell penetrating peptides; endocytosis; cell delivery; in vivo imaging; streptavidin; nanotechnology.

DOI: 10.1504/IJBNN.2011.038464

International Journal of Biomedical Nanoscience and Nanotechnology, 2011 Vol.2 No.1, pp.12 - 32

Published online: 30 Sep 2014 *

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