Title: Effect of combined Low-Dose Radon- and Hyperthermia Treatment (LDRnHT) of patients with ankylosing spondylitis on serum levels of cytokines and bone metabolism markers: a pilot study

Authors: Angelika Moder, Clemens Hufnagl, Gudrun Lind-Albrecht, Wolfgang Hitzl, Arnulf Hartl, Martin Jakab, Markus Ritter

Addresses: Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 21, A-5020 Salzburg, Austria; Gastein Research Institute, Paracelsus Medical University, Schareckstrasse 4, A-5640 Bad Gastein, Austria. ' Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 21, A-5020 Salzburg, Austria; Gastein Research Institute, Paracelsus Medical University, Schareckstrasse 4, A-5640 Bad Gastein, Austria. ' Gasteiner Kur, Reha- und HeilstollenbetriebsgesmbH, Heilstollenstrasse 19, A-5645 Bockstein/Bad Gastein, Austria. ' Research Office, Biostatistics, Paracelsus Medical University, Strubergasse 21, A-5020, Salzburg, Austria. ' Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 21, A-5020 Salzburg, Austria. ' Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 21, A-5020 Salzburg, Austria. ' Institute of Physiology and Pathophysiology, Paracelsus Medical University, Strubergasse 21, A-5020 Salzburg, Austria; Gastein Research Institute, Paracelsus Medical University, Schareckstrasse 4, A-5640 Bad Gastein, Austria

Abstract: Ankylosing Spondylitis (AS) is a rheumatic disease and almost 50% of the affected patients suffer from osteoporosis. The ratio of Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Osteoprotegerin (OPG) has become an important marker to assess the status of systemic bone metabolism and has been shown to be dysregulated in AS patients. Combined Low-Dose Radon- and Hyperthermia Therapy (LDRnHT) causes pain reduction in patients with AS and induces the cytokine transforming growth factor-β1 (TGF-β1). TGF-β1 acts as an anti-inflammatory cytokine and influences the OPG/RANK/RANKL system. We therefore performed a study on 33 AS patients to investigate the effect of LDRnHT on serum levels of bone metabolism markers and cytokines involved in chronic inflammatory disorders. It is shown that TGF-β1, TNF-α, IL-6, OPG and RANKL levels significantly increased after LDRnHT and that the ratio of OPG over RANKL is significantly elevated.

Keywords: radon; OPG; RANKL; RANK; inflammatory cytokines; TGF-beta1; ankylosing spondylitis; rheumatic diseases; osteoporosis; low radiation; serum levels; bone metabolism markers; radon therapy; hyperthermia therapy; pain reduction.

DOI: 10.1504/IJLR.2010.037663

International Journal of Low Radiation, 2010 Vol.7 No.6, pp.423 - 435

Available online: 23 Dec 2010 *

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