Title: Formulation of nanosuspensions of gymnemic acids for oral administration

Authors: R. Ravichandran

Addresses: Regional Institute of Education (NCERT), Bhopal – 462 013, India

Abstract: Integration of ayurveda and pharmaceutical technological advances are being used to make effective drug delivery system of gymnemic acids. In recent years, there has been a considerable interest in the development of novel drug delivery systems using nanotechnology. In the present work an attempt has been made to prepare and formulate gymnemic acids nanocrystal in order to improve the dissolution velocity and enhance the bioavailability. The gymnemic acids nanosuspension prepared was dried by lyophilisation and characterised for its physico-chemical properties and the re-dispersion of it in water was intensively investigated. Morphology of the particles was also analysed. Finally, gymnemic acids nanocrystal-loaded tablets were developed using direct compression and its dissolution behaviour was evaluated in various dispersion media. The improved dissolution behaviour of the gymnemic acids nanocrystal-loaded tablet should lead to a better bioavailability of the poorly soluble gymnemic acids in the body.

Keywords: gymnemic acids; nanocrystals; dissolution behaviour; nanoparticles; nanosuspensions; nanotechnology; drug delivery; dissolution velocity; bioavailability; morphology; solubility.

DOI: 10.1504/IJNP.2010.037135

International Journal of Nanoparticles, 2010 Vol.3 No.4, pp.309 - 325

Received: 05 Apr 2010
Accepted: 26 May 2010
Published online: 26 Nov 2010 *

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