Title: A convenient preparative method for 2-alkyl-γ-butyrolactones

Authors: T. Inaba, M. Sakamoto, T. Fujita, S . Watanabe

Addresses: Department of Applied Chemistry, Faculty of Engineering, Chiba University, Yayoicho, Chiba, Japan. ' Department of Applied Chemistry, Faculty of Engineering, Chiba University, Yayoicho, Chiba, Japan. ' Department of Applied Chemistry, Faculty of Engineering, Chiba University, Yayoicho, Chiba, Japan. ' Department of Applied Chemistry, Faculty of Engineering, Chiba University, Yayoicho, Chiba, Japan

Abstract: Various 2-alkyl-γ-butyrolactones (IV) were prepared from 2-acetyl-γ-butyrolactone (I) via two steps: alkylation of 2-acetyl-γ-butyrolactone (I) followed by deacetylation. For example, 2-hexyl-γ-butyrolactone (IV; R = n-C₆H₁₃) was prepared as follows: reaction of 2-acetyl-γ-butyrolactone (I) with n-hexyl bromide using sodium hydride as a base in dirnethylformamide gave 2 acetyl-2-hexyl-γ-butyrolactone (II; R = n-C₆H₁₃) with 83% yield. Deacetylation of (II; R =# n-C₆H₁₃) with sodium methoxide gave 2-hexyl-γ-butyrolactone (IV; R = n-C₆H₁₃) with 85% yield.

Keywords: 2-alkyl-γ-butyrolactones; 2-acetyl-y-butyrolactones; deacetylation; alkylation.

DOI: 10.1504/IJMPT.1989.036728

International Journal of Materials and Product Technology, 1989 Vol.4 No.2, pp.151 - 158

Published online: 06 Nov 2010 *

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