Authors: R. Ravichandran
Addresses: Regional Institute of Education (NCERT), Bhopal – 462 013, India
Abstract: Lyophilised gymnemic acids nanocrystals were intensively evaluated regarding their physicochemical properties with respect to particle size analyses, crystallinity, kinetic solubility and dissolution behaviour, and compared with microcrystals. The particle size was determined by photon correlation spectroscopy (PCS) and laser diffraction (LD). DSC and X-ray diffraction were used to study the crystalline state of gymnemic acids nanocrystals. The superior physicochemical properties observed with gymnemic acids nanocrystals over microcrystals should overcome the absorption problem in the gastrointestinal tract and increase the bioavailability.
Keywords: nanosuspension; nanocrystals; gymnemic acids; physico-chemical properties; nanotechnology; particle size; crystallinity; kinetic solubility; dissolution behaviour; microcrystals; absorption; gastrointestinal tract; bioavailability.
International Journal of Nanoparticles, 2010 Vol.3 No.3, pp.280 - 296
Received: 12 Feb 2010
Accepted: 22 Mar 2010
Published online: 07 Oct 2010 *