Article: The growth kinetics and in vitro biocompatibility of Nb2O5 microcones Journal: International Journal of Medical Engineering and Informatics (IJMEI) 2010 Vol.2 No.3 pp.247 - 260 Abstract: Metal oxides have been explored as potential surgical implant coatings designed to incorporate the biocompatibility of the surface oxide with the durable mechanical properties of the underlying metal. A novel anodisation process has been designed which generates an oxide composed of crystalline Nb2O5 microcones interspersed in an amorphous interface oxide. Thin sheets of niobium metal were anodised in a HF(aq) electrolyte for 1, 2 and 4 hrs. Scanning electron microscopy (SEM) was used to analyse the oxide features for each anodisation time. Larger and fewer microcones resulted from increased anodisation time. Due to the requirement of surgical implants to be autoclaved before implantation, the microcone features were analysed using SEM before and after autoclaving. Statistical analysis showed that the microcone features changed very little after autoclaving. MC3T3-E1 pre-osteoblast cells cultured on the autoclaved discs indicated that the 1 h and 4 h groups support the highest amount of cell proliferation. Inderscience Publishers - linking academia, business and industry through research

Title: The growth kinetics and in vitro biocompatibility of Nb₂O₅ microcones

Authors: A. Mackey, R.L. Karlinsey, A. Chern, T.G. Chu

Addresses: Indiana Nanotech, LLC, 351 West Tenth Street, Suite 222, Indianapolis, IN 46202-4119, USA. ' Indiana Nanotech, LLC, 351 West Tenth Street, Suite 222, Indianapolis, IN 46202-4119, USA. ' Department of Biology, Indiana University, Jordan Hall, 1001 East Third Street, Bloomington, IN 47405-3700, USA. ' Department of Restorative Dentistry, Indiana University School of Dentistry, 1121 W. Michigan St. Rm. DS112, Indianapolis, IN 46202, USA

Abstract: Metal oxides have been explored as potential surgical implant coatings designed to incorporate the biocompatibility of the surface oxide with the durable mechanical properties of the underlying metal. A novel anodisation process has been designed which generates an oxide composed of crystalline Nb₂O₅ microcones interspersed in an amorphous interface oxide. Thin sheets of niobium metal were anodised in a HF_(aq) electrolyte for 1, 2 and 4 hrs. Scanning electron microscopy (SEM) was used to analyse the oxide features for each anodisation time. Larger and fewer microcones resulted from increased anodisation time. Due to the requirement of surgical implants to be autoclaved before implantation, the microcone features were analysed using SEM before and after autoclaving. Statistical analysis showed that the microcone features changed very little after autoclaving. MC3T3-E1 pre-osteoblast cells cultured on the autoclaved discs indicated that the 1 h and 4 h groups support the highest amount of cell proliferation.

Keywords: niobium oxide; anodisation; autoclaving; osteoblast proliferation; microcones; metal oxides; surgical implants; implant coatings; growth kinetics; in vitro biocompatibility; bioengineering; biomedical engineering; cell proliferation.

DOI: 10.1504/IJMEI.2010.035218

International Journal of Medical Engineering and Informatics, 2010 Vol.2 No.3, pp.247 - 260

Published online: 14 Sep 2010 *

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Title: The growth kinetics and in vitro biocompatibility of Nb2O5 microcones

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Title: The growth kinetics and in vitro biocompatibility of Nb₂O₅ microcones