Title: High resolution read-out circuit for DNA label-free detection system

Authors: Daniela De Venuto, Bruno Ricco

Addresses: DEE Politecnico di Bari, via Orabona, 4 Bari, Italy. ' DEIS Universita di Bologna, Viale del Risorgimento, 2 Bologna, Italy

Abstract: This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridisation effect is monitored by means of a Charge Sensitive Amplifier (CSA) and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensors.

Keywords: DNA biosensors; biosensor read-out; charge sensitive amplifiers; differential read-out systems; DNA label-less detection.

DOI: 10.1504/IJBET.2010.034940

International Journal of Biomedical Engineering and Technology, 2010 Vol.4 No.3, pp.211 - 231

Published online: 31 Aug 2010 *

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