Title: A micro-sequenced CMOS model for cell signalling pathway using G-protein and phosphorylation cascade

Authors: S.M. Rezaul Hasan

Addresses: Center for Research in Analogue and VLSI microsystem dEsign (CRAVE), School of Engineering and Advanced Technology (SEAT), Massey University, Auckland, New Zealand

Abstract: Communication between cells in multi-cellular organisms, such as animals, humans and plants, is essential for coordinating the organismic activities of fertilisation, growth, survival and reproduction. This biochemical communication between trillions of cells in organisms can be more complex than the internet. This paper develops a CMOS circuit model of signal reception and signal transduction within a cell in response to extracellular molecular signals. A micro-sequenced model has been developed where the signal transduction steps are clocked by circadian time intervals. The model converts the chemical signalling pathway into a CMOS multi-step logical transformation cascade transducing a received signal molecule into an activated cellular protein response. This modelling technique leads to understanding cellular malfunctions (diseases) in the form of logical (electrical) faults in a circuit.

Keywords: systems biology; analogue CMOS; phosphorylation cascade; ATP; G-protein; cell signalling pathway; microsequences; circuit modelling; signal reception; signal transduction; extracellular molecular signals; cellular malfunctions; diseases; logical faults; electrical faults; adenosine triphosphate.

DOI: 10.1504/IJCAT.2010.034728

International Journal of Computer Applications in Technology, 2010 Vol.39 No.1/2/3, pp.40 - 45

Published online: 18 Aug 2010 *

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