Title: A novel integrative phylogenetic analysis system

Authors: Penghao Wang, Bing Bing Zhou, Chen Wang, Albert Y. Zomaya

Addresses: Centre for Distributed and High Performance Computing, School of Information Technologies, University of Sydney, NSW 2006, Australia. ' Centre for Distributed and High Performance Computing, School of Information Technologies, University of Sydney, NSW 2006, Australia. ' CSIRO ICT Centre, P.O. Box 76, Epping, NSW 1710, Australia. ' Centre for Distributed and High Performance Computing, School of Information Technologies, University of Sydney, NSW 2006, Australia

Abstract: Existing phylogenetic methods cannot realistically model the evolutionary process. It has become a serious issue for real-life applications which demand accurate phylogenetic results. It is desirable to have an integrative approach which can effectively incorporate multi-disciplinary analyses and synthesise results from various sources. A novel integrative and interactive computing system has been developed to address such an issue. We introduce the concept of super-quartet and explain how it is adopted for effective integration of other computational methods to the algorithm during computation – a key issue of the development of integrative and interactive computing system.

Keywords: phylogeny reconstruction; integration; interactive computing; multidisciplinary analysis; quartet-based; phylogenetic analysis; computational methods; computational biology.

DOI: 10.1504/IJCBDD.2010.034462

International Journal of Computational Biology and Drug Design, 2010 Vol.3 No.1, pp.1 - 14

Published online: 05 Aug 2010 *

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