Title: Preparation and characterisation of poly vinyl alcohol/hydroxyapatite nanocomposite via in situ synthesis: a potential material as bone tissue engineering scaffolds

Authors: S.A. Poursamar, F. Orang, S. Bonakdar, M. Khorshid Savar

Addresses: Biomedical Engineering Faculty, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran. ' Biomedical Engineering Faculty, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran. ' Biomedical Engineering Faculty, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran. ' Biomedical Engineering Faculty, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran

Abstract: Nanocomposite (NC) comprising poly vinyl alcohol (PVA), hydroxyapatite (HA) was synthesised using in situ mineralisation of HA within PVA aqueous solution. Freeze/thaw physical cross-linking along with both freeze/dry and particulate leaching methods were used to prepare porous polymeric matrix. TEM imaging ratifies formation of HA nanoparticles while FTIR analysis revealed the formation of chemical bounds among hydroxyl functional groups of PVA chains and hydroxyapatite structure. Mechanical tests were benefited to evaluate mechanical properties of the samples.

Keywords: poly vinyl alcohol; PVA; hydroxyapatite; HA; bone scaffolds; bone tissue; tissue engineering; nanocomposites; nanotechnology; nanoparticles; mechanical properties; bioengineering.

DOI: 10.1504/IJNM.2010.033875

International Journal of Nanomanufacturing, 2010 Vol.5 No.3/4, pp.330 - 334

Available online: 02 Jul 2010 *

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