Title: Decision support based on genomics: integration of data- and knowledge-driven reasoning
Authors: S. Sfakianakis, M. Blazantonakis, I. Dimou, M. Zervakis, M. Tsiknakis, G. Potamias, D. Kafetzopoulos, D. Lowe
Addresses: The Foundation for Research and Technology-Hellas, Institute of Computer Science, P.O. Box 1385, GR-71110, Heraklion, Crete, Greece. ' Department of Electronics and Computer Engineering, The Technical University of Crete, Chania 73100, Crete, Greece. ' Department of Electronics and Computer Engineering, The Technical University of Crete, Chania 73100, Crete, Greece. ' Department of Electronics and Computer Engineering, The Technical University of Crete, Chania 73100, Crete, Greece. ' The Foundation for Research and Technology-Hellas, Institute of Computer Science, P.O. Box 1385, GR-71110, Heraklion, Crete, Greece. ' The Foundation for Research and Technology-Hellas, Institute of Computer Science, P.O. Box 1385, GR-71110, Heraklion, Crete, Greece. ' The Foundation for Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, P.O. Box 1385, GR-71110, Heraklion, Crete, Greece. ' The Neural Computing Research Group, Aston University, Aston Triangle, Birmingham B4 7ET, UK
Abstract: The breadth and depth of available clinico-genomic information, present an enormous opportunity for improving our ability to study disease mechanisms and meet the individualised medicine needs. A difficulty occurs when the results are to be transferred |from bench to bedside|. Diversity of methods is one of the causes, but the most critical one relates to our inability to share and jointly exploit data and tools. This paper presents a perspective on current state-of-the-art in the analysis of clinico-genomic data and its relevance to medical decision support. It is an attempt to investigate the issues related to data and knowledge integration.
Keywords: data integration; knowledge integration; clinico-genomic knowledge discovery; bioinformatics; personalised medicine; decision support systems; medical DSS; genomics.
DOI: 10.1504/IJBET.2010.032697
International Journal of Biomedical Engineering and Technology, 2010 Vol.3 No.3/4, pp.287 - 307
Published online: 13 Apr 2010 *
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