Title: Controlled release of Berberine Chloride by electrospun core/shell PVP/PLCL fibrous membranes

Authors: Bin Sun, Shuo Li, Hong Zhang, Hua Li, Chenguang Zhao, Xiaoyan Yuan, Yuanlu Cui

Addresses: School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. ' School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. ' School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. ' School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. ' School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. ' School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China. ' Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Abstract: Berberine chloride (BC) was loaded in the core/shell structured poly(vinyl pyrrolidone)/poly(L-lactide-co-ε-caprolactone) (PVP/PLCL) by coaxial electrospinning. After hot-press at 60°C, the mechanical properties of the electrospun PVP/PLCL membrane increased significantly. A burst release of BC from the electrospun PVP/PLCL fibres incubated in PBS at 37°C was found in 1 h and the cumulative released percentage of BC could exceed 90% at 72 h, significantly higher than that of BC encapsulated in PLCL. The drug-loaded electrospun PVP/PLCL membranes could potentially enhance wound healing in skin repair.

Keywords: coaxial electrospinning; hot pressing; berberine chloride; controlled release; wound dressing; PVP-PLCL membranes; wound healing; skin repair; biomedical engineering; bioengineering; drug control release.

DOI: 10.1504/IJMPT.2010.031433

International Journal of Materials and Product Technology, 2010 Vol.37 No.3/4, pp.338 - 349

Published online: 03 Feb 2010 *

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