Title: On equation of arm gait of Huntington Disease patient

Authors: O. Ibidapo-Obe, O.O.E. Ajibola, V.O.S. Olunloyo

Addresses: Faculty of Engineering, Department of Systems Engineering, University of Lagos, Akoka, Yaba, Lagos 234(01), Nigeria. ' Faculty of Engineering, Department of Systems Engineering, University of Lagos, Akoka, Yaba, Lagos 234(01), Nigeria. ' Faculty of Engineering, Department of Systems Engineering, University of Lagos, Akoka, Yaba, Lagos 234(01), Nigeria

Abstract: Huntington|s Disease (HD) is a progressive autosomal dominant trait, which usually begins in middle age; it is characterised by choreiform movements. The genetic defect that results in HD has been traced to an unstable expanded CAG trinucleotide repeat mutation in a novel gene on the short arm of chromosome 4. In this work, an attempt is made to promote a better understanding of the physiological chorea associated with human health hazard of HD origin by proposing a mathematical model which describes the arm gait of HD patient.

Keywords: arm gait; physiological chorea; human health hazards; choreiform; huntingtin protein; Huntington|s disease; biometrics; mutation; mathematical modelling.

DOI: 10.1504/IJBM.2010.030416

International Journal of Biometrics, 2010 Vol.2 No.1, pp.53 - 70

Published online: 15 Dec 2009 *

Full-text access for editors Access for subscribers Purchase this article Comment on this article