Title: Labelling of albumin microspheres with ¹⁸⁸Re: a possible agent for radiotherapy

Authors: Virginia Nazarica Borza, Elena Neacsu, Catalina Mihaela Barna, Nicoleta Popescu-Pogrion, Ionel Mercioniu, Cristina Lavinia Nistor

Addresses: 'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' 'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' 'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' National Institute of Materials Physics, 105 bis Atomistilor Street, Bucharest – Magurele, P.O. Box MG-7, code 077125, Romania. ' National Institute of Materials Physics, 105 bis Atomistilor Street, Bucharest – Magurele, P.O. Box MG-7, code 077125, Romania.' National Research and Development Institute for Chemistry and Petrochemistry, ICECHIM, 202 Independence Street, District 6, CP 35-174, 060021 Bucharest, Romania

Abstract: Regional administration of labelled particles by intra-arterial infusion is an effective method for endoradiotherapy of tumours. The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter ¹⁸⁸Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was studied. Under optimised conditions, after 60 min reaction time, at 95°C, the reaction yield was more than 95%. Labelled microspheres were found to be stable in vitro; 43 h after labelling, 87% of ¹⁸⁸Re was bound to the microspheres.

Keywords: albumin microspheres; labelling methods; 188Re; radiotherapy; endoradiotherapy; tumours; radiolabelling; beta emitters; hepatocellular carcinoma.

DOI: 10.1504/IJNBM.2009.028342

International Journal of Nano and Biomaterials, 2009 Vol.2 No.6, pp.540 - 546

Published online: 16 Sep 2009 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article