Title: Comparative study for brain delivery of tacrine using polysorbate 80-coated poly(butylcyanoacrylate) and pegylated-poly(butylcyanoacrylate) nanoparticles

Authors: Basel A. Abdel-Wahab, Mohamed M. Abdel-Latif, Atef A. Abdel-Hafez

Addresses: Department of Pharmacology, College of Pharmacy, Najran University, Njran, Saudi Arabia. ' Department of Pharmaceutics, College of Pharmacy, Assiut University, Assiut, Egypt. ' Department of Pharmaceutical Chemistry, College of Pharmacy, Taief University, Saudi Arabia

Abstract: Many studies indicated that polysorbate (PS) 80-coated polybutylcyanoacrylate (PBCA) nanoparticles can deliver drugs that poorly penetrate BBB to the brain. Also, the polyethylene glycolated-polybutylcyanoacrylate (PEG-PBCA) nanoparticles have a good safety profiles and sustained drug release. The purpose of this study is to compare between the ability of both PS80-coated PBCA nanoparticles and PEG-PBCA nanoparticles in targeting of tacrine to the brain. Rats treated with tacrine intravenously in three forms: 1) simple solution; 2) loaded on PS80-coated PBCA nanoparticles; 3) loaded on PEG-PBCA nanoparticles. Tacrine antiamnesic effect was tested using the passive avoidance reflex (PAR) test. Also tacrine concentrations in brain and liver were measured using HPLC. Results demonstrated that, both PS-80 coated and PEG-PBCA nanoparticles successfully enhanced brain delivery of tacrine in rats while PEG-PBCA nanoparticles have higher brain targeting ability and less liability to be up taken by the liver, this provides it more safety and longer duration.

Keywords: brain targeting; blood-brain barrier; BBB; tacrine; nanoparticles; poly(butylcyanoacrylate); PBCA; Pegylted-PBCA nanoparticles; nanotechnology; drug delivery; safety.

DOI: 10.1504/IJNBM.2009.027733

International Journal of Nano and Biomaterials, 2009 Vol.2 No.1/2/3/4/5, pp.360 - 374

Published online: 08 Aug 2009 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article