Title: Lengthened duration of benefit from botulinum toxin injections for the treatment of spasticity
Authors: Chandler E. Gill, CaraLee R. Blair, Michael S. Putman, Henry M. Taylor, P. David Charles
Addresses: Vanderbilt University Medical Center, 1161 21st Avenue South, A-0118 Medical Center North, Nashville, TN 37232-2551, USA. ' PCSOM MS-IV, 2456 Adams Ave, Ashland, KY 41102, USA. ' Vanderbilt University, 2301 Vanderbilt Place, Station B, Nashville, TN 37232, USA. ' Clover Bottom Developmental Center, 275 Stewarts Ferry Pike, Nashville, TN 37214, USA. ' Vanderbilt University Medical Center, 1161 21st Avenue South, Suite A-1106 Medical Center North, Nashville, TN 37232-2551, USA
Abstract: In the setting of a spasticity management program, 26 adults with Intellectual Disability (ID) and spasticity were treated with injections of Botulinum Toxin type A. After a series of regular injections (range: 4-7 injections), three patients experienced dramatically lengthened benefit lasting an average of 22.3 months (range: 19-29). None of the patients exhibit characteristics that have been suggested to explain this phenomenon in other disorders, such as duration of illness or toxin dose. Future studies should identify which characteristics or treatment parameters predict lengthened response.
Keywords: spasticity management; lengthened benefit; remission; intellectual disability; botulinum toxins; botulism; botulinum toxin injections; illness duration; toxin dose.
The Botulinum Journal, 2008 Vol.1 No.2, pp.199 - 207
Published online: 16 Jun 2009 *Full-text access for editors Access for subscribers Purchase this article Comment on this article