Title: Modelling and parameter estimation of a cell system

Authors: Er-Wei Bai, Sunaina Fotedar, Alan Moy

Addresses: Department of Electrical and Computer Engineering, and Department of Radiology, University of Iowa, Iowa, USA. ' Kennedy Krieger Institute, John Hopkins University, Maryland, USA. ' John Paul II Stem Cell Research Institute, 540 E. Jefferson St., Suite 305, Iowa City, IA 52245, USA; Cellular Engineering Technologies, Inc., 2501 Crosspark Rd., Suite B105, Coralville, IA 52241, USA

Abstract: A non-linear identification approach for modelling endothelial cells is mathematically derived and experimentally tested under the realistic alternating current voltage and a square-like shape assumption. Results demonstrate the applicability and effectiveness of the approach. The derived model is an important step in understanding a cell system and in developing controlling and treating certain disorders by new drugs.

Keywords: system identification; parameter estimation; nonlinear systems; modelling; endothelial cells; cell systems; vascular homeostasis; blood vessels; sinusoidal AC voltage input.

DOI: 10.1504/IJMIC.2009.023532

International Journal of Modelling, Identification and Control, 2009 Vol.6 No.1, pp.72 - 80

Available online: 26 Feb 2009 *

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