Title: Histomorphological and mechanical property correlations in rabbit tibial plateau cartilage based on a fibril-reinforced biphasic model

Authors: Nurit Golenberg, Eugene Kepich, Roger C. Haut

Addresses: Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, A407 East Fee Hall, Michigan State University, East Lansing, Michigan 48824, USA. ' Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, A407 East Fee Hall, Michigan State University, East Lansing, Michigan 48824, USA. ' Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, A407 East Fee Hall, Michigan State University, East Lansing, Michigan 48824, USA

Abstract: The rabbit knee joint has frequently been used to study the mechanical properties of articular cartilage using various computational models. These models, however, vary in their ability to extract comparable material properties of cartilage from experimental data, resulting in inconsistencies in the data from various laboratories. A more complex, fibril-reinforced biphasic model more accurately fits the response of the cartilage by incorporating a collagen fibre network within the matrix. Indentation-relaxation tests were conducted on the medial and lateral facets in areas covered and uncovered by the meniscus on the rabbit tibial plateau. Gross and histological data were analysed and correlated with the mechanical properties. The fibril-reinforced biphasic model accurately fit the entire experimental curve extracting both the instantaneous (fibre modulus) and equilibrium (matrix modulus) responses and tissue permeability. The data was found significant at all sites. Significant correlations were also documented between the mechanical and the histological and morphological data.

Keywords: mechanical properties; cartilage; fibril-reinforced biphasic modelling; rabbit knee joint; indentation-relaxation test; histomorphology; permeability; fibre modulus; equilibrium modulus; collagen fibre network; experimental biomechanics.

DOI: 10.1504/IJECB.2009.022859

International Journal of Experimental and Computational Biomechanics, 2009 Vol.1 No.1, pp.58 - 75

Available online: 30 Jan 2009 *

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