Title: BIPASS: Design of alternative splicing services

Authors: Zoe Lacroix, Christophe Legendre

Addresses: Scientific Data Management Laboratory, Electrical Engineering, Arizona State University, Tempe AZ 85287-5706, USA; Translational Genomics Research Institute, 13400 E Shea Blvd, Scottsdale AZ 85259, USA. ' Scientific Data Management Laboratory, Electrical Engineering, Arizona State University, Tempe AZ 85287-5706, USA

Abstract: We analyse the motivations that led the development of services to support alternative splicing studies. We discuss data modelling issues and illustrate them with the BioInformatics Pipeline for Alternative Splicing Services (BIPASS). We identify the specific needs that an alternative splicing service should address, and compare existing services with respect to a common matrix of functionalities. We conclude with a discussion on future work needed to offer a more complete suite of services.

Keywords: alternative splicing; exons; introns; splice sites; web services; data modelling; use cases; database; conceptual model; bioinformatics.

DOI: 10.1504/IJCBDD.2008.020210

International Journal of Computational Biology and Drug Design, 2008 Vol.1 No.2, pp.200 - 217

Available online: 08 Sep 2008 *

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