Title: A lattice Boltzmann framework for simulation of thrombogenesis

Authors: S.E. Harrison, J. Bernsdorf, D.R. Hose, P.V. Lawford

Addresses: Medical Physics and Clinical Engineering, University of Sheffield, Royal Hallamshire Hospital, UK. ' NEC Laboratories Europe, NEC Europe Ltd., Sankt Augustin, Germany. ' Medical Physics and Clinical Engineering, University of Sheffield, Royal Hallamshire Hospital, UK. ' Medical Physics and Clinical Engineering, University of Sheffield, Royal Hallamshire Hospital, UK

Abstract: A lattice Boltzmann framework has been developed which models thrombus formation following physical damage to platelets and activation of the coagulation cascade via one or more of the strands of Virchow|s triad. The model includes concurrent simulation of flow, activation of blood and modification of the geometry following clot deposition. An extended local clotting rule has been developed which considers the vicinity of the growing clot and local flow factors such as shear stress. This paper will focus on the implementation of these local rules, as an extension to the standard flow solver, for modelling the activation and clotting processes.

Keywords: blood clotting; lattice Boltzmann method; simulation; thrombogenesis; thrombus formation; platelet damage; coagulation cascade; modelling.

DOI: 10.1504/PCFD.2008.018084

Progress in Computational Fluid Dynamics, An International Journal, 2008 Vol.8 No.1/2/3/4, pp.121 - 128

Available online: 30 Apr 2008 *

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