Title: Analytical simulation of interfacial DNA hybridisation for design of an optimal nanotechnology handheld biosensor

Authors: Samuel Abiodun Afuwape

Addresses: National University, SOET, San Diego, CA 92123, USA; P.O. Box 301244, Escondido, CA 92030, USA

Abstract: DNA biosensors are becoming ubiquitous at current scale-level of nanotechnology; but still remain in research laboratory. The project objective is accessing feasibility for a commercial off-the-shelf optimally designed versatile handheld DNA biosensor. Therefore, thorough understandings of the principles behind design of DNA biosensor during biophysical interfacial transduction were explored. The Grahame equation was graphically solved at the electrolyte insulator interface of the DNA biosensor. Ion selective field-effect transistor (ISFET), integrated into nanotechnology, presents a suitable transduction platform to implement the benchmark protocol of DNA biosensors. Moreover, the identification or extraction of the optimal intrinsic and extrinsic parameters may in essence lead to stable, selective, sensitive, and a reliable optimally applicable DNA biosensor. This paper focuses on the simulation of essential mathematical and literature circuit equivalent models of interfacial DNA hybridisation. Model transfer functions were derived and the tools of control system theory were implemented for their usefulness to design an optimal nano-scaled DNA biosensor.

Keywords: interfacial DNA hybridisation; DNA biosensors; hybridisation; ISFET; modelling; nanoparticles; simulation; nanotechnology; handheld sensors; handheld biosensors; sensor design; nanosensors.

DOI: 10.1504/IJNT.2008.017451

International Journal of Nanotechnology, 2008 Vol.5 No.4/5, pp.534 - 565

Available online: 07 Mar 2008 *

Full-text access for editors Access for subscribers Purchase this article Comment on this article