Title: Effect of nanoscale topography on fibronectin adsorption to sputter deposited calcium phosphate thin films

Authors: Marie-Louise Cairns, Brian J. Meenan, George A. Burke, Adrian R. Boyd

Addresses: Nanotechnology and Integrated Bioengineering Centre (NIBEC), University of Ulster, Shore Road, Newtownabbey, Co. Antrim, Northern Ireland BT37 0QB, UK. ' Nanotechnology and Integrated Bioengineering Centre (NIBEC), University of Ulster, Shore Road, Newtownabbey, Co. Antrim, Northern Ireland BT37 0QB, UK. ' Nanotechnology and Integrated Bioengineering Centre (NIBEC), University of Ulster, Shore Road, Newtownabbey, Co. Antrim, Northern Ireland BT37 0QB, UK. ' Nanotechnology and Integrated Bioengineering Centre (NIBEC), University of Ulster, Shore Road, Newtownabbey, Co. Antrim, Northern Ireland BT37 0QB, UK

Abstract: Fibronectin (FN) adsorption to Calcium Phosphate (CaP) thin film surfaces with topographical features in the submicron to nanometre range has been investigated. CaP thin films have been produced by Radio-Frequency (RF) magnetron sputter deposition and a sputtered Titanium (Ti) interlayer was used to create substrates with nanoscale surface features. Detailed X-ray Photoelectron Spectroscopy (XPS) analysis of the FN ad-layers indicated differences in the nature of the adsorption on the main surface types. Binding studies revealed that the FN had a stronger affinity for the CaP on sputtered Ti. These data suggest that nanoscale topography can influence FN adsorption on CaP thin film surfaces.

Keywords: calcium phosphate; CaP; fibronectin adsorption; FN; protein adsorption; nanoscale topography; sputter deposition; thin films; nanomaterials; thin film surfaces.

DOI: 10.1504/IJNBM.2008.016876

International Journal of Nano and Biomaterials, 2008 Vol.1 No.3, pp.280 - 298

Available online: 26 Jan 2008 *

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