Title: Modelling on the mechanical properties of nanocomposite hydroxyapatite/PMMA/carbon nanotube coatings

Authors: Tolou Shokuhfar, Elby Titus, Gil Cabral, Antonio C.M. Sousa, Jose Gracio, Waqar Ahmed, Thomas Okpalugo, Ahmed Makradi, Said Ahzi

Addresses: Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, University of Aveiro, Aveiro 3810-193, Portugal. ' Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, University of Aveiro, Aveiro 3810-193, Portugal. ' Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, University of Aveiro, Aveiro 3810-193, Portugal. ' Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, University of Aveiro, Aveiro 3810-193, Portugal. ' Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, University of Aveiro, Aveiro 3810-193, Portugal. ' School of Computing, Technology and Physical Sciences, University of Central Lancashire, Preston PR1 2HE, UK. 'Nanotechnology and Integrated Bioengineering Centre, University of Ulster, UK. ' University Louis Pasteur, Strasbourg 1, CNRS, Inst Mecan Fluides and Solides, UMR 7507, Strasbourg 67000, France. ' University Louis Pasteur, Strasbourg 1, CNRS, Inst Mecan Fluides and Solides, UMR 7507, Strasbourg 67000, France

Abstract: A combination of Hydroxyapatite (HA), Polymethylmethacrylate (PMMA) and Carbon Nanotubes (CNTs) was used to synthesize a new composite material, which is superior in mechanical properties to the conventional HA as a biomedical scaffold in tissue engineering. PMMA is well-known as a bone cement highly compatible with HA and can act as a functionalising/linking and/or coupling agent with the HA-CNTs mixtures, while the unique and excellent structure and properties of CNTs, after functionalisation, are able to reinforce and strengthen the porous HA matrix. The evolution of the secondary phases of HA may impair the mechanical properties; however, the evolving species (calcium oxide, tetra-calcium and tri-calcium phosphates or amorphous calcium phosphates) are trapped in the CNTs-PMMA network yielding a nanocomposite with improved mechanical and longer lasting lifetime performance, based on preliminary observations, shows good biocompatibility, and a detailed study to evaluate its biocompatibility is underway. The experimental study was characterised by means of X-Ray Diffraction (XRD), vibrational Raman spectroscopy and Scanning Electron Microscopy (SEM).

Keywords: carbon nanotubes; CNTs; polymethylmethacrylate; PMMA; hydroxyapatite; HA; nanocomposites; scaffolds; bone replacement; tissue engineering; nanotube coatings; nanomaterials; biocompatibility.

DOI: 10.1504/IJNBM.2007.016555

International Journal of Nano and Biomaterials, 2007 Vol.1 No.2, pp.107 - 115

Published online: 10 Jan 2008 *

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