Title: Linear state space model for long-term blood pressure regulation

Authors: M. Shahin, S. Maka

Addresses: Department of Electrical Engineering, Indian Institute of Technology, Kharagpur 721302, India. ' Department of Electrical Engineering, Indian Institute of Technology, Kharagpur 721302, India

Abstract: Abnormal cardiovascular regulation acts as a potential trigger of hypertension, which is one of the main problems in modern societies. The purpose of the present work is to describe the non-linear cardiovascular system in a state variable form, suitable for applying control theory techniques. A linear state variable description of long-term Arterial Blood Pressure (ABP) regulation has been developed for the analysis of the system|s properties. The influence of the system|s parameters on the stability and dynamic behaviour is analysed using eigen values. The closed loop poles of the system under normal and pathological conditions have been evaluated through the root locus technique, which indicates some applications of prediction and diagnosis. The simulation results show that the linear model yields a performance which is very close to that of the actual non-linear model.

Keywords: arterial blood pressure; ABP; eigenvalues; long-term regulation; modelling; nervous activity; renal system; state variables; blood pressure regulation; control theory; cardiovascular system; hypertension; simulation; biomedical engineering.

DOI: 10.1504/IJBET.2007.015860

International Journal of Biomedical Engineering and Technology, 2007 Vol.1 No.2, pp.190 - 203

Published online: 25 Nov 2007 *

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