Title: Pharmacogenomics: analysing SNPs in the CYP2D6 gene using amino acid properties

Authors: Mark T.W. Ebbert, Wesley A. Beckstead, Timothy D. O'Connor, Mark J. Clement, David A. McClellan

Addresses: Department of Integrative Biology and Computer Science, Brigham Young University, 3370 TMCB, Provo, Utah 84602, USA. ' Department of Integrative Biology, Brigham Young University, 3370 TMCB, Provo, Utah 84602, USA. ' Department of Integrative Biology, Brigham Young University, 3370 TMCB, Provo, Utah 84602, USA. ' Department of Computer Science, Brigham Young University, 3370 TMCB, Provo, Utah 84602, USA. ' Department of Integrative Biology, Brigham Young University, 699 WIDB, Provo, Utah 84602, USA

Abstract: The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous substitution using the program TreeSAAP. Our results show four SNPs in CYP2D6 that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D6 gene and contribute to a person|s inability to metabolise specific drugs.

Keywords: pharmacogenomics; single nucleotide polymorphisms; SNPs; amino acid properties; CYP2D6 gene; bioinformatics; biochemical properties; drug metabolisation.

DOI: 10.1504/IJBRA.2007.015415

International Journal of Bioinformatics Research and Applications, 2007 Vol.3 No.4, pp.471 - 479

Published online: 15 Oct 2007 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article